In a significant advancement within the clean beauty sector, Tri-En Bio Co., Ltd., led by CEO Kim Yong-soo, has launched the DEEPOELE™ Damask-PDRN Liposome, a product that integrates the potent regenerative properties of DNA extracted from the prized Damask rose with plant-distilled rose water.
This combination not only enhances cellular regeneration and hydration but also targets signs of aging, promising a multifaceted approach to skin health.
The DEEPOELE™ formulation employs an innovative liposome-based delivery system to encapsulate the Damask rose DNA (Sodium DNA) sourced from the floral extracts and the distilled water.
This advanced technology increases the safety and skin absorption of the active ingredients, ensuring they perform effectively upon application.
Emphasizing sustainability, Tri-En Bio's latest offering aligns with the growing demand for ethically sourced raw materials in the clean beauty trend, positioning the DEEPOELE™ as a high-functioning bio-material that fuses premium plant-derived PDRN with cutting-edge liposome technology.
**The Synergy of Plant-Derived PDRN and Liposome Technology**
PDRN, known for promoting the self-regeneration of damaged cells and tissues, traditionally utilized salmon testis as a source for its DNA extraction.
However, due to ethical trends steering away from animal-derived materials and concerns around fish mortality and infections, the spotlight is now on plant-derived PDRN (Phyto-PDRN).
This transition enhances the appeal of Tri-En Bio’s innovative offering.
Liposomes, defined as nano-sized spherical vesicles composed of phospholipid bilayers similar to skin cell membranes, function as 'artificial bio-capsules' which securely transport active ingredients into the skin.
This delivery mechanism is particularly beneficial for sensitive components such as vitamins and peptides, protecting them from degradation caused by external factors such as light and heat.
Upon application, liposomes seamlessly fuse with the skin, enhancing the bioavailability and delivery of active ingredients.
**Key Efficacies and Mechanisms of DEEPOELE™ Damask-PDRN Liposome**
1. **Enhanced Skin Regeneration**: The Damask-PDRN activates the Adenosine Receptor Pathway, which prevents inflammation and stimulates tissue regeneration.
In wound healing experiments, Damask-PDRN demonstrated a concentration-dependent increase in cellular regeneration, outperforming its salmon-derived counterpart, confirming its effectiveness in rejuvenating skin.
2. **Superior Hydration and Brightening Effects**: Renowned for its historic value, the Damask rose is rich in Vitamin C and polyphenols, making it a long-standing ingredient for anti-aging.
This ingredient aids in hydration by promoting the synthesis of hyaluronic acid while inhibiting hyperpigmentation through the suppression of the enzyme tyrosinase, resulting in brighter, more luminous skin.
3. **Mechanism of Action**: - **Hydration Improvement**: Damask-PDRN prompted a dose-dependent increase in gene expression of AQP-3 and HAS2, crucial for skin hydration.
Results indicated a higher efficacy than that of Salmon PDRN, suggesting a reversal of aging trends.
- **Brightening Impact**: By inhibiting tyrosinase activity, Damask-PDRN blocks melanin production.
The degree of inhibition also showed a dose-dependent increase, paving the way for a more uniform skin tone, thereby addressing visible aging signs.
**Safety and Versatility of DEEPOELE™ Damask-PDRN Liposome**
Safer than many alternatives in the market, the DEEPOELE™ formulation demonstrated over 90% cell survival rates at DNA concentrations of 10 ppm and 20 ppm, confirming its non-cytotoxic nature.
Moreover, human patch testing indicated negligible skin irritation, affirming DEEPOELE™ as a safe option for sensitive skin types.
Ultimately, the DEEPOELE™ Damask-PDRN Liposome exemplifies the fusion of potent skin-rejuvenating properties of Damask rose PDRN with state-of-the-art liposome technology.
This product not only enhances the stability and delivery of active components but also positions itself as a cornerstone of the ‘Slow & Reverse Aging’ philosophy, promising to shape the future of plant-derived PDRN ingredients in the clean beauty landscape.
