Amorepacific announced on the 10th that it has developed a next-generation cosmetic delivery technology utilizing nanotechnology in collaboration with Professor Choi Si-young's research team at KAIST. The results of this research were featured on the cover of ACS Nano's May issue (Vol 20, Issue 17) under the title 'Triterpenoids Bend and Bind Lipid Membranes into 20 nm Stable Nanocages.' This development represents a significant milestone in the field of cosmetic ingredient delivery, crucial for enhancing product efficacy and consumer satisfaction.

The collaborative research accomplished a remarkable feat by successfully reducing the size of lipid-based carriers to approximately 20 nanometers, while maintaining a stable structure that avoids collapse. This breakthrough is particularly relevant given that the current iteration of stable nanocarrier technology is being applied in products from brands like Iope and Primera under the designation 'Lipo3Ex.' The ability to produce smaller, yet more stable carriers opens new avenues for product development and consumer engagement.

Typically, the efficacy of cosmetic delivery systems improves with smaller ingredient sizes; however, maintaining structural stability becomes increasingly challenging at nanoscale levels. The research identifies a natural ingredient, triterpenoids, which enhances the stability of these nanocarriers by fortifying inter-molecular bonds. This balance between ultra-small size and structural integrity is critical for operational effectiveness in the cosmetic realm.

This technological advancement demonstrates substantial improvements in skin penetration during human trials, allowing active ingredients to disperse evenly into deeper layers of the skin. As a result, the technology promises not only to deliver the active ingredients more uniformly across the skin but also to foster consistent skin condition improvement—a crucial factor for long-term skin health management, aligned with the emerging 'skin longevity' model.

Moreover, advanced analytical techniques, including cryo-electron microscopy, X-ray scattering analysis, and molecular dynamics simulations, were employed to meticulously validate the formation and stability of the nanostructures at a molecular level. This rigorous scientific foundation aids in positioning Amorepacific’s technological advancements beyond experiential marketing, providing a data-backed framework for future delivery system designs.

Seobyeong Hwi, CTO of Amorepacific’s R&I Center, stated, 'The research emphasizes the significance of delivery technology as a pivotal element in translating the potential of ingredients into actual efficacy, particularly in skincare products. By integrating nanoscience into our study, we unveil new technological possibilities.' He further emphasized that Amorepacific has consistently led research from a holistic longevity solution perspective, viewing the skin as an integrated system for long-term health management. This achievement is expected to be a vital foundation for developing next-generation skincare solutions.