LG Household & Health Care announced on the 30th that it has discovered a new solution aimed at alleviating female pattern hair loss without relying on steroid-derived ingredients. This innovative approach is being hailed as a significant development in the limited and often restrictive treatment options that have traditionally dominated the field.

Presented at the World Congress for Hair Research (WCHR) in Seoul, the findings underscore the company’s commitment to addressing a critical gap in treatment methodologies for female hair loss. Historically, therapeutic options have been constrained, with male hormone suppressants being unsuitable for women and estrogen-based therapies raising concerns over side effects and applicability.

In its research, LG Household & Health Care confirmed that non-steroidal substances derived from vitamin A can activate the estrogen receptor alpha (ERα), thereby stimulating follicular activity and enhancing the scalp environment conducive to hair growth. Lead researcher Jaeyoon Kim noted the substance's potential in promoting hair follicle activation and improving hair thickness, as evidenced by clinical evaluations.

This study represents a pivotal expansion of the research parameters within the hair loss sector. Unlike previous studies that primarily focused on dermal papilla cells, LG Household & Health Care’s findings suggest that activating estrogen receptors can simultaneously target dermal papilla and hair follicle stem cells, thereby broadening the therapeutic potential.

Moreover, LG Household & Health Care’s strategic use of AI technology significantly enhances the robustness of their research. Analyzing approximately 420,000 candidate substances, their AI simulations assessed potential interactions with hair follicle-related proteins and combined metabolic data linked to female pattern hair loss, leading to the identification of ERα as a key therapeutic target.

Additionally, the study introduced 'Rhamsydil,' a new material under development geared towards improving hair thickness and follicular health. Research indicates that Rhamsydil reduces the expression of DKK1 (Dickkopf-1), a factor that induces the transition to hair follicle regression, thereby fostering a more favorable environment for hair growth. Similar to the previous findings, Rhamsydil has been shortlisted through AI-driven analysis that condensed the exploration timeline from 22 months to just a day.

Chief Technology Officer Naegyu Kang emphasized the transformative potential of this study for managing female pattern hair loss, stating that LG Household & Health Care will continue to enhance research on scalp aging mechanisms in partnership with their AI research division to develop next-generation scalp and hair care solutions integrating 'Scalp Longevity' principles.