Amorepacific's R&I Center announced on the 10th that it has integrated microbiome and surface metabolite analyses to identify key substances associated with youthful and healthy skin. This groundbreaking research was published online in the international microbiology journal 'International Microbiology' in April (paper title: Integrated analysis of age-related microbiome and metabolites reveals youth-associated metabolites in young Korean women’s skin).

The study emphasizes the integral role of skin microbiomes in influencing skin health and aging, adding a layer of sophistication to existing research. By not only analyzing the composition and dynamics of the skin microbiome but also elucidating its correlations with skin barrier, immunity, and aging, Amorepacific is reinforcing its research capabilities. This paper showcases the comprehensive results derived from a cross-disciplinary approach.

Focusing on Korean women, the research identified phenyllactic acid (PLA) as a significant metabolite that manifests in environments characterized by youthful and healthy skin. Experimental findings further indicate that PLA promotes collagen production and inhibits the activity of collagen-degrading enzymes. This underscores the direct correlation between microbiome-generated substances and skin aging management, representing a strategic advancement in the understanding of skin health.

By integrating microbiomes within the framework of skin condition assessments, the research challenges traditional age-centric interpretations of skin aging. The findings advocate that skin microbiomes serve not just as passive ecosystems but as active partners in determining skin health. Amorepacific anticipates leveraging these insights for developing personalized skin diagnostics and functional materials based on microbiome research.

Building on these findings, Amorepacific plans to broaden its research into next-generation skin longevity materials, with the aim of fostering healthier and more youthful-looking skin regardless of age. The technology derived from this study related to microbiome-derived metabolites holds promise for a wider array of skincare product developments moving forward.

According to Seo Byeong-hwi, CTO of Amorepacific R&I Center, “Our enduring commitment to microbiome research seeks to provide a fundamental understanding of skin health. The discovery of key substances associated with youthful skin is highly significant.” He added, “We will continue our research from a ‘Holistic Longevity Solution’ perspective, helping maintain the skin's healthy environment and contribute to achieving a younger and healthier appearance.”